Chaga Mushroom Health Benefits

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    Immunostimulation Mechanism of Action Oxalic, gallic, protocatechuic and p-hydroxybenzoic acids have been identified in chaga extracts In vitro, antidiabetic effects are attributed to terpenoids that inhibit alpha-glucosidase Anti-inflammatory and pain-relieving properties may occur via inhibition of nitric oxide synthase iNOS and cyclooxygenase-2 COX-2 3.

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    Anti-quorum sensing activity in chaga conks suggests broader anti-infection attributes beyond immunomodulatory effects In animal studies, a methanolic extract of chaga produced beneficial effects on learning and memory via decreased malondialdehyde and nitrite levels, decreased acetylcholinesterase activity, and restored glutathione, superoxide dismutase, and acetylcholine levels Antifatigue effects were attributed to polysaccharides from chaga, which increased endurance and glycogen content of liver and muscle in mice, while decreasing blood lactic acid and serum urea nitrogen levels Prostatis eleutherococcus effects in animal colitis models were related to suppression of tumor necrosis factor TNF -alpha, iNOS, and interleukin IL -1beta Water-soluble lignin derivatives have also been identified as bioactive constituents with anticancer properties A hot-water extract of chaga exhibited inhibitory and proapoptotic actions against colon cancer cells via upregulation of Bax and caspase-3 and downregulation of Bcl-2 5.

    Inhibition of colorectal cancer was exerted by the constituent ergosterol via downregulation of the beta-catenin pathway Inotodiol, a triterpenoid isolated from chaga, inhibited proliferation of cervical cancer cells and induced apoptosis in vitro via increased Bax expression, decreased Bcl-2, cyclin E downregulation, and p27 up-regulation Other apoptotic characteristics can induce caspase cleavage and nuclear fragmentation gomba chaga a prosztatitis.

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    Adverse Reactions Oxalate nephropathy: Associated with the ingestion of chaga mushroom powder teaspoons daily for 6 monthsin a year-old woman with liver cancer End stage renal disease: Following long-term consumption of chaga mushroom, in a year-old hasi prosztatitis Herb-Drug Interactions Antiplatelet or anticoagulant drugs: Chaga extract inhibited platelet aggregation in a murine model 2.

    Hypoglycemic agents: In vitro, chaga had additive effects in lowering blood sugar levels Clinical significance is yet unknown.

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