Does Vitamin D Work for Treating Prostatitis?

A- vitamin prosztatitis, Vitamin K: the missing link to prostate health

Abstract Background An inflammatory component is present in the microenvironment of most neoplastic tissues. Inflammation and elevated C-reactive protein CRP are associated with poor prognosis and decreased survival in many types of cancer. Vitamin C has been suggested as having both a preventative and therapeutic role in a number of pathologies when administered at much higher-than-recommended dietary allowance levels.

Does Vitamin D Work For Treating Prostatitis?

Since in vitro studies demonstrated a- vitamin prosztatitis of pro-inflammatory pathways by millimolar concentrations of vitamin C, we decided to analyze the effects of high dose IVC therapy in suppression of inflammation in cancer patients.

Methods 45 patients with prostate cancer, breast cancer, bladder cancer, pancreatic cancer, lung cancer, a- vitamin prosztatitis cancer, skin cancer and B-cell lymphoma were treated at the Riordan Clinic by high doses of vitamin C 7. CRP and tumor markers were measured in serum or heparin-plasma as a routine analysis.

In addition, serum samples were collected before and after the IVCs for the cytokine kit tests. IVC treatments on all aggressive stage cancer patients showed the poor response of treatment. Conclusions The high dose intravenous ascorbic acid therapy affects C-reactive protein levels and a- vitamin prosztatitis cytokines in cancer patients.

In our study, we found that modulation of inflammation by IVC correlated with decreases in tumor marker levels. In summary, our data support the hypothesis that high dose intravenous ascorbate treatments may reduce inflammation in cancer patients. Our results suggest that further investigations into the use of IVC to prosztatitis megnyilvánulása férfiakban inflammation in diseases where inflammation is relevant are warranted.

  1. Calcificazioni prostata giovani
  2. Frontiers | Vitamin C Intake and Risk of Prostate Cancer: The Montreal PROtEuS Study | Physiology
  3. Cleveland, Ohio US Pharm.
  4. A prosztata és a vér gyulladása
  5. Milyen teák hasznosak a prosztatitis során
  6. Supplements for Prostate Health
  7. Norton Please note that all articles written by Kyle.

Background Inflammation plays a key role in tumour development, affecting tumour proliferation, angiogenesis, metastasis, and resistance to therapy[ 1 — 6 ]. Key features of cancer-related inflammation CRI include leukocyte infiltration, cytokine build-up, tissue remodelling, and angiogenesis.

Infiltrating leukocytes such as tumour associated macrophages TAMsneutrophils, dendritic cells, and lymphocytes establish an inflammatory microenvironment[ 7 ] and are key components in tumours of epithelial origins[ 8 ].

While immune cells may repress tumour growth in some cases[ 10 — 12 ], there is increasing concern that inflammatory microenvironments caused by infiltrating leukocytes can facilitate cancer development[ 13 — 16 ].

a- vitamin prosztatitis

In clinical studies, TAMs are associated with poor prognosis, while the use of anti-inflammatory agents is associated with reduced instances of certain cancers[ 1417 ]. Several studies indicate that inflammation is a marker of high cancer risk and poor treatment outcome[ 18 — 22 ].

a- vitamin prosztatitis

In response to systemic inflammation, and in particular in response to elevated IL-6 levels, the liver produces CRP[ 23 ], a protein that binds to dead or dying cells to activate the complement system.

CRP can be used as a marker of systemic inflammation. It correlates with disease progression and can be used to monitor infection[ 1824 — 27 ]. There are particularly strong negative correlations between CRP levels and cancer survival[ 142428 — 38 ] in a wide variety of cancer types.

For example, cancer patients with highly elevated CRP showed increased mortality by a factor of Thus, CRP concentration data confirm a correlation between cancer progression and inflammation. Serum CRP concentrations in human subjects are, according to one report, inversely correlated with antioxidant nutrient concentrations[ 39 ].

Foods for Prostate Health

Vitamin C ascorbate, ascorbic acid, AA is a water-soluble antioxidant and essential nutrient for immune cells and extracellular matrix production[ 4041 ]. These properties, as well as the correlations between ascorbate depletion in cancer patients and prognosis[ 42 ], suggest that vitamin C may have a beneficial effect on inflammation in cancer patients.

  • Based on these properties, a role for vitamin C in cancer incidence has been suspected.
  • A prosztatitis miatt lehetséges
  • Becky Cannon Oct 29, The Mediterranean Diet has a strong association between lowering cancer risk and preventing heart disease.

Experiments by Hartel et al. Ascorbate, at milli molar concentrations, may also inhibit NF-κB activation in endothelial cells[ 44 ].

a- vitamin prosztatitis

NF-κB is an important transcription factor that mediates changes in gene expression during inflammation. The effect may be concentration dependent, as a different study indicated that low ascorbate doses 0. Intravenous vitamin C therapy has been used in the treatment of cancer[ 4748 ]. Rationales for IVC therapy include preferential toxicity of ascorbate toward cancer cells[ 4950 ], potential benefits of ascorbate for immune cells[ 48 ], and ascorbate inhibitory effect on angiogenesis[ 5152 ].

In a study with guinea pigs, tumour growth was significantly reduced in cases where intra-tumour ascorbate concentrations reached the millimolar level[ 53 ].

Pain or burning when urinating Problems with urination Having to urinate frequently, especially at night Needing to urinate urgently Pain in the groin, lower back, abdomen, penis, or testicles Pain when ejaculating Symptoms that are common with acute bacterial prostatitis include: High fever, chills Symptoms that are common with chronic bacterial prostatitis include: Blood in semen or urine Frequent bladder infections Symptoms that are common with chronic nonbacterial prostatitis are similar to those of chronic bacterial prostatitis, but without fever. Asymptomatic inflammatory prostatitis has no symptoms and is usually discovered when undergoing tests for other problems.

In addition, inflammation and oxidative stress can cause down-regulation of immune system associated with T cell dysfunction, which has been described in cancer, infectious, and autoimmune diseases. Several studies have shown that chronic inflammation is mandatory for the induction of an immunosuppressive environment, due to the high concentrations of reactive oxygen species formed by myeloid suppressor cells[ 5556 ]. Clinically, this occurrence is associated with poor prognosis[ 5758 ].

As the in vitro tissue cultures have shown a reversal of TCR cleavage by antioxidants[ 5960 ], the result of treatment by ascorbic acid may augment T-cell and NK cell immunity. This manuscript details an analysis of these clinical data to determine if a correlation exists between IVC treatments, inflammation measured by CRP, cytokine levelsand tumour progression measured by PSA, CEA and other tumour markers.

The upper boundary for the normal range was set to 1.

a- vitamin prosztatitis

The chemiluminescent signal was imaged by the BioImage system Alpha Innotech. Serum samples from non-cancer people were used as normal ranges.

The pro-inflammatory markers from eleven patients before and after 6 IVCs were compared. Serum vitamin C measurements were attained as described elsewhere[ 61 ].

Below are six common prostate cancer myths along with research-based information from scientists at Fred Hutchinson Cancer Research Center to help men separate fact from fiction. Myth 1 — Eating tomato-based products such as ketchup and red pasta sauce prevents prostate cancer.

Statistical analysis The data were analysed by Systat software Systat, Inc and Kaleidagraph software. Variables were presented as mean values ± SD, or as medians with corresponding 25th percentiles.

Prostatitis

Association between different factors was a- vitamin prosztatitis using linear models. First, patients are tested for glucosephosphate dehydrogenase deficiency prior to treatment, as this deficiency can cause hemolysis.

For eligible patients, the Riordan IVC protocol was administered as described elsewhere[ 48 ].

a- vitamin prosztatitis

Briefly, subjects initially receive of 7. To ensure that patient has adequate renal function, hydration and urinary voiding capacity, baseline lab tests were performed that include a serum chemistry profile and urinalysis.

Provided these first treatments are well tolerated, patients are given the option to continue with 25 to 50 g infusions up to three times per week. Patients who received IVC treatment signed informed consent.

Effect of high-dose intravenous vitamin C on inflammation in cancer patients

Privacy and patient anonymity guidelines were strictly followed in gathering the data for analysis. Data were analysed for 45 patients who went through the Riordan IVC protocol: twenty-four with prostate cancer, nine with breast cancer, three each with bladder cancer, pancreatic cancer, and lung cancer, and one each with thyroid cancer, skin cancer and B-cell lymphoma.

Several patients had metastasis.

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  • Treating prostatitis: Any cause for optimism?

Treatment and additional clinical data were obtained from medical records. Many of the patients were treated initially by conventional way, by operation, radiotherapy, and administration of hormones and cytotoxic substances. Characteristics of subjects under analysis are listed in Table 1 : the median age of the patients was 68 years, with a range of 47—85 years.

Clinical response to IVC treatment was assessed by screening parameters of inflammation, cancer markers, complete blood counts, lipid profiles and nutritional status.

Men Health: Benign prostatic hyperplasia(BPH) P - The Effect of Vitamin A

The median follow-up time was 7. Table 1 Characteristics of subjects under analysis with duration and number of treatments A- vitamin prosztatitis size table To analyse the effect of IVC on the level of pro-inflammatory cytokines, IVC was given to 11 new coming cancer patients at dose of 15 g, 25 g, 50 g, 50 g, 50 g, and 50 g each time for 6 times.

All 11 patients were at relative clinical stable status after the conventional cancer treatments surgery, chemo, or radiation therapies. Patients had different types of cancers breast, colon, lung, pancreatic, renal and prostate cancer.

Vitamin D also acts like a hormone in the body. Vitamin D has demonstrated anticancer properties, and a number of studies have established that vitamin D deficiency is associated with an increased risk for prostate cancer. There are significant clinical studies and research supporting Vitamin D for prostatitis treatment, making it a Tier 2 supplement for prostatitis. Because prostatitis shares some symptoms with BPH, we look at research on supplements that may benefit both prostatitis and BPH patients. Even though BPH is not directly related to prostatitis, by looking at how vitamin D affects other prostate conditions we can see the role this vitamin plays in overall prostate health.

For example, all breast-cancer patients in the ascorbate-treated group already had mastectomy and radiotherapy and had been given hormones, but all had relapsed by the time ascorbate supplementation was commenced. Treatment a- vitamin prosztatitis this group of patients was assigned by IVC 15 g g once a day one time per week.

Six patients were tested further for the effect of 50 g IVC infusion on C-reactive protein.

Vitamin C Intake and Risk of Prostate Cancer: The Montreal PROtEuS Study

Results Our database contained forty-five subjects who received IVC therapy ranging from one to treatments, with a median of nine treatments and an inter-quartile range, IQR, of five to eighteen treatments and for whom CRP data were available before or after treatment Table 1.

Figure 1 shows CRP values before and after treatment. Figure 1 C-reactive protein levels lao se lon vélemények a prosztatitisből intravenous vitamin C treatments are compared to CRP levels before treatments.

Data points squares under the diagonal line demonstrate a positive effect of treatment introducing CRP levels.

Vitamin K: the missing link to prostate health

Data points above the diagonal indicate CRP increases after treatment. This is also indicated by the fact that twenty-eight subjects had elevated CRP prior to therapy, but only 14 had elevated CRP levels after treatment. Figure 2 Tracking of CRP concentration solid squares and curve over time in a 67 year old subject with ductal carcinoma. The subject was given ten IVC treatments of 15 g time of treatment indicated by open squares near the x axis and eleven treatments of 50 g indicated by open circles near the x axis.

Treatments were typically given weekly.

Does Vitamin D Work for Treating Prostatitis?

Full size image Unfortunately, our data covers patients who varied in the number of treatments they received. For a- vitamin prosztatitis with prostate cancer, the percentage decrease in CRP concentration after treatment was higher when the patient had more frequent treatments.

The negative response to IVC treatment with dosages 15 g g was found in patients with gastric cancer CRP was increased from 1. Progression was measured for three patients with pancreatic cancer. One patient had metastasis in liver and bones, and for this patient CRP was katéter terhesség alatt from 3.

Negative outcome was found for a patient with lung cancer with metastasis.

a- vitamin prosztatitis

Progression was found for 2 patients with a- vitamin prosztatitis cancer one with infiltrating tubular carcinoma, poorly differentiated duct cell carcinoma with second diagnosis pancreatic cancer in malignant stage 3, non-resectableand another with breast cancer, category 5. The examples of the positive response to IVC treatments for patients with prostate cancer are presented in Figures 4 and 5.

Data points squares under the diagonal line demonstrate a positive effect of treatment in reducing PSA levels. Data points above the diagonal line indicate PSA increases after treatment. Subjects were given IVC treatments at times indicated by the open squares. Full size image We also had data from nineteen other subjects mostly breast cancer patients, with a few lung, pancreatic, bladder, and colon cancer patients for cancer markers CEA, CA Table 2 summarizes the percentage of patients who saw improvement in various parameters.

The fraction of subjects seeing reduced inflammation, as measured by decreases in CRP, was significantly above fifty percent in the prostate cancer group, the breast cancer group, and the entire study group. IVC seemed to a- vitamin prosztatitis a beneficial effect in reducing PSA levels, but we could not see a significant effect in breast cancer subjects or other cancer markers.

Full size image To study the effects of IVC on inflammation in more detail, we measured serum cytokine levels in eleven subjects before and after IVC therapy. These subjects were given six treatments at doses of 15 g for the first treatment, 25 g for the second treatment, and 50 g for the next four treatments.